Expression and polymorphisms of T cell immunoglobulin domain and mucin domain protein-1 in thymoma with or without myasthenia gravis
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چکیده
منابع مشابه
Expression and polymorphisms of T cell immunoglobulin domain and mucin domain protein-1 in thymoma with or without myasthenia gravis
The present study aimed to investigate the expression and association of the single-nucleotide polymorphism (SNP) -1637A/G in the promoter region of the T cell immunoglobulin domain and mucin domain protein-1 (Tim-1) gene in patients diagnosed with thymoma with or without myasthenia gravis (MG). The expression of Tim-1 was detected using the streptavidin peroxidase immunohistochemical staining ...
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Thymoma is a type of benign or low-grade malignant tumor, occurring on the thymic epithelium. Patients with thymoma may also suffer from myasthenia gravis (MG), presenting MG-associated thymoma. T cell immunoglobulin and mucin domain-3 (Tim-3), a subtype of the Tim protein family, may be an important immune regulatory and pivotal molecule associated with tumor development. In order to understan...
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condition targeting the neuromuscular junction. Thymomas have been found in 10-15% of patients with acquired MG suggesting a paraneoplastic origin in these cases, and approximately onethird are designated as malignant with invasion of the capsule. Patients with thymoma are slightly older and more often have generalized symptoms compared to MG patients without thymoma.1 Although familial autoimm...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2014
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2014.2090